Annual report pursuant to Section 13 and 15(d)

Organization and Description of Business - Additional Information (Detail)

v3.6.0.2
Organization and Description of Business - Additional Information (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]    
Net loss $ (26,671) $ (15,529)
Cash flows from operating activities (23,353) (23,324)
Accumulated deficit (422,959) $ (396,288)
Cash and cash equivalents and marketable securities 17,000  
Cash received from from financings 9,400  
Cash received from license agreement $ 5,000