Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Significant components of the Company’s deferred tax assets are as follows (in thousands):


	December 31
	2015			2014
Deferred tax assets:
Federal and state net operating loss carryforwards	$	79,966		$	71,153
Capitalized research and development		22,287			22,314
Federal and state tax credit carryforwards		7,571			7,083
Other		2,012			1,470

Total deferred tax assets		111,836			102,020
Valuation allowance		(111,836	)		(102,020	)

Net deferred tax assets	$	—		$	—

The following is a reconciliation of the expected statutory federal income tax provision to the actual income tax provision (in thousands):


	December 31
	2015			2014
Expected income tax benefit at federal statutory tax rate	$	(5,280	)	$	(10,851	)
Net operating loss adjustments		1			(1,703	)
Change in valuation allowance		9,815			11,189
State income taxes, net of federal benefit		(618	)		(783	)
Permanent items		(3,543	)		2,595
Research credits		(375	)		(446	)
Other, net		—			(1	)

Income tax (benefit) expense	$	—		$	—

The following table summarizes activity related to the Company’s gross unrecognized tax benefits (in thousands):


	Total
Balances as of December 31, 2013	$	1,865
Increases related to prior year tax positions		—
Increases related to 2014 tax positions		126

Balances as of December 31, 2014	$	1,991
Increases related to prior year tax positions		—
Increases related to 2015 tax positions		136

Balances as of December 31, 2015	$	2,127