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Debt - Additional Information (Detail) (USD $)
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0 Months Ended | 3 Months Ended | 9 Months Ended | 1 Months Ended | 0 Months Ended | 0 Months Ended | |||||||||||||||||||
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Sep. 30, 2013
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Sep. 30, 2013
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Sep. 30, 2013
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Sep. 30, 2014
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Jun. 20, 2006
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Dec. 31, 2010
Series E-1 Preferred [Member]
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Jul. 31, 2009
Series C-1 Preferred [Member]
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Feb. 28, 2009
Series C-1 Preferred [Member]
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Jan. 31, 2012
Series C-1 Preferred [Member]
As Amended [Member]
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Mar. 31, 2008
First Issuance [Member]
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Sep. 30, 2008
Second Issuance [Member]
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Feb. 28, 2009
Third Issuance [Member]
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Jul. 31, 2013
Third Issuance [Member]
As Amended [Member]
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Mar. 31, 2013
Third Issuance [Member]
As Amended [Member]
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Jan. 31, 2012
Third Issuance [Member]
As Amended [Member]
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Jul. 31, 2009
Fourth Issuance [Member]
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Jul. 31, 2013
Fourth Issuance [Member]
As Amended [Member]
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Mar. 31, 2013
Fourth Issuance [Member]
As Amended [Member]
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Jan. 31, 2012
Fourth Issuance [Member]
As Amended [Member]
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Sep. 30, 2013
Facility Loan Agreement [Member]
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Sep. 30, 2013
Facility Loan Agreement [Member]
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Sep. 30, 2013
Facility Loan Agreement [Member]
First Tranche [Member]
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Sep. 30, 2013
Facility Loan Agreement [Member]
Scenario one, conversion basis [Member]
Second Tranche [Member]
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Sep. 30, 2013
Facility Loan Agreement [Member]
Scenario two [Member]
Second Tranche [Member]
Wall Street Journal Prime Rate [Member]
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Sep. 30, 2013
Warrants, Exercise price of $5.00 per share [Member]
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| Debt Instrument [Line Items] | |||||||||||||||||||||||||
| Maximum borrowing capacity | $ 10,000,000 | $ 10,000,000 | $ 30,000,000 | $ 10,000,000 | |||||||||||||||||||||
| Notes issued | 3,500,000 | 10,500,000 | 7,000,000 | 6,700,000 | |||||||||||||||||||||
| Maturity date of debt | Mar. 17, 2011 | Sep. 17, 2011 | Feb. 28, 2012 | Dec. 31, 2013 | Aug. 01, 2013 | Mar. 01, 2013 | Jul. 31, 2012 | Dec. 31, 2013 | Aug. 01, 2013 | Mar. 01, 2013 | |||||||||||||||
| Facility loan, fixed interest rate | 7.57% | 7.57% | 4.42% | 4.919% | 4.96% | 5.46% | 8.75% | ||||||||||||||||||
| Conversion price | $ 232.93 | $ 438.84 | $ 438.84 | $ 292.56 | |||||||||||||||||||||
| Interest expense | 200,000 | 600,000 | |||||||||||||||||||||||
| Loan facility, outstanding principal and accrued interest settled | 16,900,000 | ||||||||||||||||||||||||
| Loan facility extinguished in exchange of common stock | 624,944 | ||||||||||||||||||||||||
| Facility loan, drawn | 4,853,000 | 5,000,000 | |||||||||||||||||||||||
| Facility loan, interest amortization period | 36 months | ||||||||||||||||||||||||
| Facility loan, final interest payment | 300,000 | ||||||||||||||||||||||||
| Facility loan, financial covenants | Until positive Phase 2b data is achieved, the Company must be in compliance with one of two financial covenants at all times (1) maintain 1.3 times cash to outstanding debt or (2) maintain sufficient cash on hand to support eight months of operations based on a trailing average monthly cash burn. | ||||||||||||||||||||||||
| Facility loan, fixed interest rate | 8.75% | ||||||||||||||||||||||||
| Facility loan, prime rate plus | 4.25% | ||||||||||||||||||||||||
| Facility fee | 1.00% | ||||||||||||||||||||||||
| Warrants issued | 121,739 | ||||||||||||||||||||||||
| Exercise price | $ 5.00 | ||||||||||||||||||||||||
| Long term warrant liability | $ 400,000 | $ 500,000 | |||||||||||||||||||||||